Glossary entry

German term or phrase:

Knorpelgerüststoffe

English translation:

cartilage building components/structural components / cartilagineous matrix

Added to glossary by David Williams
Jul 26, 2010 06:42
13 yrs ago
1 viewer *
German term

Knorpelgerüststoffe

German to English Medical Medical (general) Trauma therapy
Context:

"Im Körper und vor allem im blutigen Gelenkerguss lokal freigesetzte Entzündungsfaktoren führen nachweislich zur verminderten Synthese von Knorpelgerüststoffen, zum verstärkten Zellgerüstabbau und schließlich zum programmierten Knorpelzelltod."
http://www.schattenblick.de/infopool/medizin/fachmed/mz1no23...
Change log

Jul 28, 2010 09:18: David Williams changed "Edited KOG entry" from "<a href="/profile/62748">David Williams's</a> old entry - "Knorpelgerüststoffe"" to ""cartilage building components""

Discussion

MMUlr Jul 26, 2010:
@David, IMO "synthesis of cartilage material" is too general and does not reflect the German ...stoffe. These are actually big proteoglycans (such as aggrecan ....) present in the extracellular matrix of cartilage.

See the first sentence of this article: http://jb.oxfordjournals.org/cgi/content/abstract/124/4/687 (and you may find several more examples incl. structural components (mostly in articles not freely accessible).
Bernd Runge Jul 26, 2010:
or cartilage builders?
David Williams (asker) Jul 26, 2010:
How about "cartilage material"? i.e. "... lead to a reduction in the synthesis of cartilage material, to increased cytoskeletal degeneration and, ultimately, to cartilage cell apoptosis."

Proposed translations

+1
3 hrs
Selected

cartilage building components

Supplementation of Glucosamine and Chondroitin help to build and repair cartilage, protect existing cartilage from premature breakdown, lubricate joints, decrease joint pain and stiffness, slow progression of OA and improve ease of movement. Collagen Type II helps promote new cartilage synthesis.
...
Remember that there is no one single ingredient that can provide all the materials needed to build cartilage. Many people with joint pain take only glucosamine without realising they require more cartilage- building components. When chondroitin, Collagen Type II and HA are taken together with glucosamine, your joint cartilage gets the vital and optimum nourishment for it to grow strong and healthy.

http://www.medical-explorer.com/osteoporosis.php?011
Peer comment(s):

agree gangels (X)
5 hrs
Thank you, gangels
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4 KudoZ points awarded for this answer. Comment: "Many thanks!"
29 mins

the components of the cartilaginous framework

Knorpelgerüst Knorpelgerüst n <med> • cartilaginous framework; framework of cartilages ...
books.google.at/books?isbn=386117233X...
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2 hrs

cartilagineous matrix

In a strict anatomical sense, this suggestion is not 100% exact, but it might work well in a context like yours.

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Note added at 5 hrs (2010-07-26 11:43:15 GMT)
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Cartilage basically consists of two components: water and a framework of structural macromolecules (matrix) that give the tissue its form and function. ...
www.cartilage.org/index.php?pid=22&lang=1

Peer comment(s):

neutral MMUlr : Wäre schon eine Interpretation (es steht ja nicht Matrix da) - IMO waren die Proteoglykane in der ECM gemeint, nicht unbedingt die ECM selbst./s. meine Added note - Anne, hier der (ganz seltene!) Fall, wo wir unterschiedlicher Meinung sind ;-)
1 hr
Weiß schon, dass das nicht 1:1 übersetzt ist, aber wo es eher auf allgemeine Abläufe als auf einzelne biochemische Reaktionen ankommt, scheint es mir genau genug (siehe z.B. Verwendung der Terminologie in der added note).
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10 mins

cartilage structural components

see e.g.:
http://catalyst.rice.edu/archives/40

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Note added at 4 hrs (2010-07-26 11:04:25 GMT)
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Another ref. for structural components ... find the first sentence of the "Introduction" (-> pdf scan of the 1st page of the article):

http://www.springerlink.com/content/u4g895v048n45917/

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Note added at 1 day6 hrs (2010-07-27 13:29:18 GMT)
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@Anne, ich habe den Absatz in der URL gelesen;

"Cartilage basically consists of two components: water and a framework of structural macromolecules (matrix) that give the tissue its form and function. The matrix is highly organized and composed of collagens, proteoglycans and noncollagenous proteins."

... du meinst demnach, man könne einfach das Wasser "ignorieren" und Matrix = Makromoleküle verstehen ... Also, die Notwendigkeit zu dieser Vereinfachung sehe ich nicht, wo doch ein gute eingeführter, auch noch verständlicher Ausdruck wie "structural components" vorhanden ist. :-)

Außerdem sind die "Gerüststoffe" eben nicht alle Moleküle in der ECM, sondern nur bestimmte, IMO Kollagen und Proteoglykane.

Sehr interessant übrigens dieser Dissertatin zum "Thema":
http://edoc.ub.uni-muenchen.de/7790/1/sicking_barbara.pdf


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Note added at 1 day6 hrs (2010-07-27 13:30:15 GMT)
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sorry, typos: "gut eingeführter ..." --- Dissertati*o*n
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