ratón ICR ICR mouse

Creator:	John Cutler
Language pair:	Spanish to English
Discipline:	-
Definition / notes:	An ICR mouse is short for "Imprinting Control Region" mouse. Imprinting is the mammalian phenomena whereby expression of a gene occurs only from one of the two alleles, the other having been silenced. Usually (as I'm sure you know) gene expression occus equally from both the maternal and paternal alleles. ICR mice are used in the genetics lab to investigate the function of genes. We also use the term "knock-out" and "knock in" to refer to cases where genes have been removed or added to the genome. Genes with common functions often appear in groups, so that they can share regulatory elements (non-coding RNAs and differentially methylated regions (DMRs)). When this happens, the regulatory elements controlling their imprinting are known as imprinting control regions (ICR's). Probably the best known example of this in mice appear on chromosome 17, and is called "Air". Source(s):
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